Effects of modafinil on pentylenetetrazol-induced convulsive epilepsy
نویسندگان
چکیده
منابع مشابه
Effects of modafinil on pentylenetetrazol-induced convulsive epilepsy.
Modafinil, is a wake-promoting drug approved by Food and Drugs Administration (FDA) for narcolepsy and sleep-apnoe syndrome. Although the mechanism underlying its arousal action remains elusive, it is known to increase glutamatergic, histaminergic, noradrenergic and dopaminergic transmission and decrease GABA release in different regions of the brain, which are all known to be involved in patho...
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Introduction: Epilepsy is a neurological disorder caused by uncontrollable discharge of neurons in the brain. After a seizure oxidative stress play an important role in the oxidative neuronal damage. In this study, we evaluated the anticonvulsant and antioxidant effects of pioglitazone, a PPAR-γ agonist that is used in type2 diabetes, on pentylenetetrazol-induced seizure in mice. Methods: In t...
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ژورنال
عنوان ژورنال: Bratislava Medical Journal
سال: 2015
ISSN: 1336-0345
DOI: 10.4149/bll_2015_033